徐玉泉
一、主要履历及经历
1994年毕业于北京农业大学,获学士学位;2001年,获中国农业大学生物学院农学博士学位。2001年8月-2006年1月,中国农业科学院生物技术研究所工作,期间,于2003年2月-2003年6月,法国国家科学研究中心访问。2006年2月-2013年8月,先后在美国亚利桑那大学农学院和美国加州大学圣地亚哥分校药学院从事博士后研究工作。
二、研究领域
利用新的技术和方法发现对农业和医学有重要价值的微生物天然产物;研究微生物天然产物多聚酮和非核糖体多肽的生物合成及其调控机制;利用重组酶生物合成新的生物活性物质。研究结果对于了解微生物天然产物对植物的调控作用;病原菌通过天然产物诱导的作物致病机理;发现新的微生物活性物质用于预防和防治农作物病害;创造可以在农业、工业以及医药上应用的新型化合物等方面具有重要的价值。
先后主持过国家自然科学基金项目“细菌调控蛋白MphR突变体与酚类污染物互作的分子机理研究”和国家863计划项目“运动发酵单胞菌发酵途径中乙醇合成等相关重要功能基因的研究”等课题。获得2004年度法国法中促进科学技术研究协会(AFCRST)陈氏兄弟生物技术奖。
研究成果分别发表在Nature子刊 Nature Chemical Biology、Cell子刊 Chemistry & Biology、Proceedings of the National Academy of Sciences、Journal of the American Chemical Society和Angewandte Chemie-International Edition等国际著名期刊上。
三、发表论文
1.Xu Yuquan *, Tong Zhou*(*Equal contribution), Shuwei Zhang, Li-Jiang Xuan, Jixun Zhan , and István Molnár. 2013. Thioesterase Domains of Fungal Nonreducing Polyketide Synthases Act as Decision Gates during Combinatorial Biosynthesis. Journal of the American Chemical Society. 135 (29):10783–10791
2.Xu Yuquan *, Tong Zhou*(*Equal contribution), Zhengfu Zhou , Shiyou Su , Sue A Roberts , William R. Montfort , Jia Zeng , Ming Chen , Wei Zhang , Min Lin , Jixun Zhan , Istvan Molnar. 2013. Rational reprogramming of fungal polyketide first ring cyclization. Proceedings of the National Academy of Sciences. 110 (14):5398-5403
3.Xu Yuquan, patricia Espinosa-Artiles, Vivien Schubert, Ya-ming Xu, Wei Zhang, Min Lin, A.A. Leslie Gunatilaka, Roderich Sussmuth, and Istvan Molnar. 2013. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat-shock response modular anticancer fungal polyketide from Aspergillus terreus. Applied and Environmental Microbiology. 79(6):2038-2047
4.Gonzalezi David*, Yuquan Xu*, Yu-Liang Yang*(*Equal contribution), Eduardo Esquenazi, Wei-Ting Liu, Anna Edlund, Tram Duong, Liangcheng Du, István Molnár, William H. Gerwick, Paul R. Jensen, Michael Fischbach, Chih-Chuang Liaw, Paul Straight, Victor Nizet, and Pieter C. Dorrestein. 2012. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. Journal of Proteomics. 75(16):5069-5076
5.Matthes Diana, Lennart Richter, Jane Müller, Alexander Denisiuk, Sven C. Feifel, Yuquan Xu, Patricia Espinosa-Artiles, Roderich D. Süssmuth and István Molnár. 2012. In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues. Chemical Communications. 48(45):5674-5676
6.Yang Yu-Liang *, Yuquan Xu* (*Equal contribution), Roland Kersten, Wei-Ting Liu, Michael Meehan, Bradley S. Moore, Nuno Bandeira and Pieter C. Dorrestein. 2011. Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. Angewandte Chemie-International Edition. 50(26):5839-5842
7.Kersten Roland D, Yu-Liang Yang, Yuquan Xu, Peter Cimermancic, Sang-Jip Nam, William Fenical, Michael A Fischbach, Bradley S Moore, and Pieter C Dorrestein. 2011. A mass spectrometry–guided genome mining approach for natural product peptidogenomics. Nature Chemical Biology. 7(11): 794-802
8.Liu Wei-Ting*, Yu-Liang Yang*, Yuquan Xu* (*Equal contribution), Anne Lamsa, Nina M. Haste, Jane Y. Yang, Julio Ng, David Gonzalez, Craig D. Ellermeier, Paul D. Straight, Pavel A. Pevznere, Joe Pogliano, Victor Nizet, Kit Pogliano, and Pieter C. Dorrestein. 2010. Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proc Natl Acad Sci U S A. 107(37):16286-16290.
9.Yang Yu-Liang*, Yuquan Xu* (*Equal contribution), Paul Straight, and Pieter C. Dorrestein. 2009. Translating metabolic exchange with imaging mass spectrometry. Nature Chemical Biology. 5(12):885-887
10.Xu Yuquan, Rousel Orozcob, E.M. Kithsiri Wijeratne, Patricia Espinosa-Artiles, A.A. Leslie Gunatilaka, S. Patricia Stock, and István Molnár. 2009. Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana. Fungal Genetics and Biology. 46(5):353-364
11.Yuquan Xu, E.M. Kithsiri Wijeratne, Patricia Espinosa-Artilles, A.A.Leslie Gunatilaka, and Istvan Molnar. 2009. Combinatorial scrambling of the cyclooligomer depsipeptide cell migration inhibitor beauvericin by mutasynthesis with Beauveria bassiana ATCC 7159. ChemBioChem. 10(2):345-354
12.Wang Shuhao*, Yuquan Xu* (*Equal contribution), Erin A. Maine, E.M. Kithsiri Wijeratne, Patricia Espinosa-Artiles, A.A. Leslie Gunatilaka, and István Molnár. 2008. Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone from Chaetomium chiversii. Chemistry & Biology. 15(12):1328-1338
13.Xu Yuquan, Rousel Orozco, E.M. Kithsiri Wijeratne, A.A.Leslie Gunatilaka, S. Patricia Stock, and Istvan Molnar. 2008. Biosynthesis of the cyclooligomer depsipeptide beauvericin, a virulence factor of the entomopathogenic fungus Beauveria bassiana. Chemistry & Biology. 15(9):898-907.
14.Xu Yuquan, Jixun Zhan, E.M. Kitshiri Wijeratne, Anna M, Burns, A.A. Leslie Gunatilaka, and Istvan Molnar. 2007. Cytotoxic and anti-haptotactic beauvericin analogs from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC7159. Journal of Natural Products. 70 (9).1467-1471.